IMMUNOHISTOCHEMICAL EVALUATION OF VIMENTIN IN ENDOTHELIUM OF VESSELS OF UTERO-PLACENTAL BED DURING THE IRON DEFICIENCY ANEMIA IN PREGNANCY

Iron deficiency anemia in pregnant women (IDA) is a pressing problem modernobstetrics, the frequency of which reaches 85 %. In previous studies, we have found thatduring gestation against background IDA placental bed uterus morphologicallyhas signs gestational immaturity, severity correlates with degree ofanemia. Vimentin main intermediate protein cytoskeleton, expressed inendothelial and other cells mesenchyme. mediates tissue processes suchas cell adhesion, migration, invasion, angiogenesis vasculogenesis. order to verifythe previously obtained data on morphometric parameters hemodynamics placentalbed depending elucidation morphogenesis ofutero- form insufficiency due usedthe method immunohistochemical visualization vimentin endothelium variousvessels utero- area.Purpose work – determine features immune expression thevascular uterine- region iron theapect chronic at 37-40 weeks gestation.Materials methods. 140 biopsies were morphologically studied,obtained during caesarean section, observations physiological pregnancy gestationagainst I-III terms insufficiency. Theconcentration hemoglobin blood woman was criterion IDAseverity according medical records. According A.P. Milivanov classificationof (1999), it diagnosedby Doppler examination followed by detection morphological equivalents.Results. An increase immunoexpression indices as marker preservationof part leiomyocytes incomplete transformation, withthe immaturity uteroplacental area (UPA) themost essential clinical UPA IDA, wasmarked all cases walls spiralarteries. For endothelial venous vessels, this trend increasing optical densityof staining for characteristic only I II degrees, while thebackground III isufficiency vimentinimmunoexpression are lower than those pregnancy. endothelialcells vessels microcirculatory tract there moderate decrease opticaldensity degrees without placentalisufficiency, but degreea slight noted. At level immunoimaging is1,5 times comparison These probablydue attenuation vasculogenesis uterineplacental II-III well dyscirculatory phenomenaand damage vascular endothelium.Conclusions. During anemia, theplacental has immaturity. The revealed featuresof different types give thepossibility consider that preconditions formed hypoperfusionof development disturbances outflowfrom predictors chronicplacental